The school started in the 1960s as Pillar Secondary School under the Pillar Hindu community of Mbale, Uganda.
In 1972, its name was changed to Mbale High School when the Asians departed under President Amin's rule. It came under a Board of Directors, among whom was Mr. Mavire, who bought it from the departed Asians' Custodian Board.
In 1944, the Hindu community repossessed it from the government.
In 1945, the government again bought it from the Hindu community at a certain fee, but only part of the former school.
The school is a mixed 'O' and 'A' level institution, and the current Headteacher is Mr. Wambalo Stephen.